Kodi Nitric Oxide ndi chiyani?

Nitric oxide ndi mpweya wopangidwa ndi maselo omwe amakhudzidwa ndi kutupa komwe kumayenderana ndi mphumu ya allergic kapena eosinophilic.

Kodi FeNO ndi chiyani?

Kuyesa kwa Fractional exhaled Nitric Oxide (FeNO) ndi njira yoyezera kuchuluka kwa nitric oxide mu mpweya wotuluka. Kuyesa kumeneku kungathandize kuzindikira mphumu mwa kuwonetsa kuchuluka kwa kutupa m'mapapo.

Chithandizo cha FeNO cha Zamankhwala

FeNO ingapereke chithandizo chosavulaza pozindikira koyamba mphumu ndi ATS ndi NICE akuchilimbikitsa ngati gawo la malangizo awo apano komanso njira zodziwira matenda.

Mafupikitsidwe: ATS, American Thoracic Society; FeNO, fractional exhaled nitric oxide; GINA, Global Initiative for Asthma; ICS, corticosteroid yopumira; NICE, National Institute for Health and Care Excellence.

Malangizo a ATS amafotokoza kuchuluka kwa FeNO kwa akuluakulu monga >50 ppb, 25 mpaka 50 ppb, ndi <25 ppb, motsatana. Mu ana, kuchuluka kwa FeNO kwapamwamba, kwapakati, ndi kotsika kumafotokozedwa ngati >35 ppb, 20 mpaka 35 ppb, ndi <20 ppb (Table 1). ATS imalimbikitsa kugwiritsa ntchito FeNO kuthandizira kuzindikira mphumu komwe kumafunika umboni weniweni, makamaka pakupeza kutupa kwa eosinophilic. ATS imafotokoza kuti kuchuluka kwa FeNO kwapamwamba (>50 ppb mwa akuluakulu ndi >35 ppb mwa ana), ikamasuliridwa m'njira yachipatala, imasonyeza kuti kutupa kwa eosinophilic kulipo ndi corticosteroid response mwa odwala omwe ali ndi zizindikiro, pomwe kuchuluka kochepa (<25 ppb mwa akuluakulu ndi <20 ppb mwa ana) kumapangitsa kuti kuchuluka kumeneku kukhale kosayembekezereka komanso kwapakati kuyenera kutanthauziridwa mosamala.

Malangizo a NICE omwe alipo pano, omwe amagwiritsa ntchito milingo yotsika ya FeNO kuposa ATS (Table 1), amalimbikitsa kugwiritsa ntchito FeNO ngati gawo la kafukufuku wofufuza komwe kuzindikira mphumu kukuganiziridwa mwa akuluakulu kapena komwe kuli kusatsimikizika kwa matenda mwa ana. Magawo a FeNO amatanthauziridwanso m'njira yachipatala ndipo mayeso ena, monga kuyezetsa kwa bronchial provocation kungathandize kuzindikira matendawa powonetsa kuyankha mopitirira muyeso kwa mpweya. Malangizo a GINA amavomereza udindo wa FeNO pozindikira kutupa kwa eosinophilic mu mphumu koma pakadali pano sakuwona udindo wa FeNO mu ma algorithms ozindikira mphumu. Scottish Consensus imafotokoza ma cutoff malinga ndi kupezeka kwa steroid ndi ma values ​​​​abwino a >40 ppb mwa odwala omwe alibe steroid komanso >25 ppb kwa odwala omwe ali ndi ICS.