mankhwala

Kodi Nitric oxide ndi chiyani?

Nitric oxide ndi mpweya wopangidwa ndi maselo omwe amakhudzidwa ndi kutupa komwe kumayenderana ndi mphumu ya mphumu kapena eosinophilic.

FeNO ndi chiyani?

Mayeso a Fractional exhaled Nitric Oxide (FeNO) ndi njira yoyezera kuchuluka kwa nitric oxide mu mpweya wotuluka.Kuyezetsa kumeneku kungathandize kuzindikira matenda a mphumu mwa kusonyeza mlingo wa kutupa m'mapapo.

Clinical Utility ya FeNO

FeNO ikhoza kupereka chithandizo chosagwirizana ndi matenda oyambirira a mphumu ndi ATS ndi NICE akuvomereza kuti ndi gawo la malangizo awo amakono ndi njira zowonongeka.

Chidule cha mawu: ATS, American Thoracic Society;FeNO, fractional ex- haled nitric oxide;GINA, Global Initiative for Asthma;ICS, kutulutsa corticosteroid;NICE, National Institute for Health and Care Excellence.

Malangizo a ATS amatanthawuza milingo ya FeNO yapamwamba, yapakatikati, ndi yotsika mwa akulu ngati> 50 ppb, 25 mpaka 50 ppb, ndi <25 ppb, motsatana.Ali ana, ma FeNO apamwamba, apakati, ndi otsika amafotokozedwa kuti> 35 ppb, 20 mpaka 35 ppb, ndi <20 ppb (Table 1).ATS imalimbikitsa kugwiritsa ntchito FeNO kuthandizira matenda a mphumu kumene umboni weniweni ukufunika, makamaka pozindikira kutupa kwa eosinophilic.ATS imalongosola kuti ma FeNO apamwamba (> 50 ppb mwa akuluakulu ndi> 35 ppb mwa ana), atamasuliridwa muzochitika zachipatala, amasonyeza kuti kutupa kwa eosinophilic kulipo ndi kuyankha kwa corticosteroid kwa odwala omwe ali ndi zizindikiro, pamene otsika (<25 ppb akuluakulu). ndi <20 ppb mu ana) zimapangitsa izi kukhala zosayembekezereka komanso zapakati ziyenera kutanthauziridwa mosamala.

Malangizo apano a NICE, omwe amagwiritsa ntchito magawo otsika a FeNO odulidwa kuposa ATS (Table 1), amalimbikitsa kugwiritsa ntchito FeNO monga gawo la ntchito yowunikira komwe kuwunika kwa mphumu kumaganiziridwa mwa akulu kapena komwe kuli kusatsimikizika kwa matenda mwa ana.Miyezo ya FeNO imatanthauziridwanso muzochitika zachipatala ndikuyesedwa kwina, monga kuyesa kwa bronchial provocation kungathandize kuzindikira mwa kusonyeza kuopsa kwa airway hyperresponsiveness.Malangizo a GINA amavomereza udindo wa FeNO pozindikira kutupa kwa eosinophilic mu mphumu koma pakali pano sakuwona gawo la FeNO mu njira zowunikira matenda a asthma.Scottish Consensus imatanthawuza kudulidwa molingana ndi kuwonetsa kwa steroid ndi zabwino za> 40 ppb mwa odwala steroid-naive ndi> 25 ppb kwa odwala pa ICS.